Scream 7

In Woodsboro, Stab franchise fan Scott and his girlfriend Madison visit Stu Macher's house after hearing rumors that he might have survived having a television thrown on his head. They are killed by Ghostface, who sets the house on fire.

In Pine Grove, Indiana, Sidney Prescott has built a new life for herself. She is married to police officer Mark Evans, runs a coffeehouse, and looks after her children, including her teenage daughter Tatum, named after Sidney's late best friend Tatum Riley. Sidney receives a call from Ghostface, who requests a videocall and reveals himself as an aged and scarred Stu. Stu announces he is going after Tatum and is standing outside the theater where she and her classmates are rehearsing. Sidney arrives with the police as Ghostface flees after killing Tatum's classmates Hannah and Aaron.

Later that night, Ghostface emerges from Sidney's attic and holds Tatum at knifepoint. Mark attacks him but is knocked out after falling down the stairs. Sidney takes Tatum to a safe room to evade Ghostface and uses the room's alternate exit to leave the house. Ghostface chases them but is fatally run over by Gale Weathers and her assistants Mindy and Chad Meeks-Martin. Once Ghostface is unmasked, Sidney recognizes him as a suspicious man that bought coffee from her earlier, and the police discovers he is Karl Gibbs, a murderer who escaped from a nearby mental institution. Sidney and Gale obtain more information about Karl from institution supervisor Marco, who also recognizes Stu as a recently released "John Doe" that had no memory from before he was in Woodsboro and lived in the room next to Karl.

Mindy speculates that since Ghostface always has a personal connection to the target, Tatum should bring all of her friends together in one place. While Sidney agrees to be interviewed by Gale on television to lure in Stu's attention, Tatum, her boyfriend Ben, and her friends Chloe and Lucas meet at a tavern. Unbeknownst to them, Mark is ambushed and repeatedly stabbed by Ghostface at home.

When the interview ends, Stu calls Sidney and warns that he is outside the tavern, prompting her to leave. Tatum becomes suspicious of Ben when she finds a laptop in his car running a test to deepfake his face into Stu; she knocks him out and runs away. Ghostface kills Chloe and Lucas and injures the Meeks twins before chasing Tatum through the streets. Ben finds her, but Ghostface kills him and Tatum flees to Sidney's coffeehouse. Sidney calls Tatum and tells her to lock herself in the office and retrieve a gun from the safe. Following Sidney's instructions, Tatum shoots Ghostface from behind a wall, but once outside the office, she finds a second Ghostface at the front door.

Stu calls Sidney and reveals Tatum is being held captive at home. Sidney finds a televised message from Stu, who then proceeds to change his face into previous Ghostfaces Nancy Loomis and Roman Bridger, as well as Sidney's close friend and Gale's late husband Dewey Riley, to tell Sidney he is returning to how the Woodsboro killings started: a person being forced to watch a captive beloved at home. Sidney goes outside and finds Tatum tied to a chair while Ghostface holds her at knifepoint. Ghostface reveals himself as Marco, who explains he used his previous experience in information technology to create "Stu". He then drags in a wounded Mark and the other Ghostface unmasks to reveal Sidney's neighbor Jessica. She explains that after reading Sidney's autobiography, she came to the conclusion that Sidney succeeded because she killed those who tormented her, prompting Jessica to murder her abusive husband.

When Sidney disappeared from public life and was not present during the New York City killings, Jessica was disappointed and, discovering where Sidney had moved to, spent time at the mental institution where she met Marco. She ultimately moved next door to Sidney with her son Lucas, whom she killed in the tavern as she considered him too similar to her husband. Jessica explains she will turn Tatum into the new Sidney by repeating the traumatic events that turned her into a final girl, but Mark cuts Tatum free and she attacks Jessica as Sidney shoots Marco dead. Jessica flees and Sidney chases her before they fight, only stopping once Tatum shoots Jessica. As Jessica attacks again, Sidney and Tatum repeatedly shoot her in the head.

In the aftermath, Mark is taken to the hospital, and Sidney thanks Gale for having her back and tells Tatum about her namesake. With Gale's blessing, Mindy provides an impromptu news report about the night's events.