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Meek but hard-working corporate strategist Linda Liddle looks forward to a long-deserved promotion promised by her former boss, which she expects his son Bradley Preston to give her upon becoming CEO. Instead, Bradley gives the promotion to Donovan, a recent hire and his old fraternity brother. He intends to have Linda transferred to a dead-end position out of disgust for her boorish manner and lack of self-confidence and charisma.

When Linda protests Bradley's decision, he is impressed by her bravado and asks her to accompany him, Donovan, and two other executives on a business trip to Bangkok to finalize the company's impending merger. During the flight, Donovan humiliates Linda by playing a clumsy audition tape she recorded for Survivor, showcasing her extensive survival skills. Flying through a storm, the plane suffers engine failure and begins to lose altitude. As the cabin undergoes explosive decompression, a panicking Donovan attempts to strangle Linda and to take her seat before she stabs him with a fork in self-defense. Donovan, the rest of the passengers, and the flight attendant are blown out of the hole in the fuselage while Linda and Bradley are secure in their seats. The plane soon crashes into the sea, breaks apart on impact and quickly sinks.

Linda frees herself and wakes up the next morning beached on a remote island in the Gulf of Thailand. She finds Bradley but no other survivors. Linda builds a shelter and obtains food and water. Bradley, unable to move due to an injured leg, accepts her help but continues to treat her like a subordinate. Linda responds by abandoning him for two days; just as he collapses from thirst, Linda returns and gives him water. Bradley remains defiant and tries to build his own camp. When his efforts fail, Bradley swallows his pride and allows Linda to take the lead. Linda is proficient at fishing and even manages to kill a wild boar. One day, while foraging on the other side of the island, she notices a boat sailing offshore, but deliberately avoids attracting the attention of the occupants.

Linda becomes stronger and more confident as she teaches Bradley lessons in survival. She appears smitten with Bradley, calling him "sweetie". One night, while sharing homemade fruit wine, Linda drunkenly confesses to Bradley that she was married to a man who abused her until she allowed him to drive drunk, causing his death. Seemingly moved, Bradley offers to repay Linda by cooking dinner. He spikes the food with poisonous berries and attempts to flee on an improvised raft, leaving Linda to die. The raft is destroyed in the waves, and Linda, partially recovered due to Bradley's ignorance about the poison dosage, is able to save him from drowning.

As punishment, Linda paralyzes Bradley with octopus toxin and pretends to castrate him, explaining that with her career effectively over, she has nothing to return home to. Bradley finally accepts that the power dynamic has shifted and gives up hope of escape. While harvesting fruit, Linda is surprised by the arrival of Bradley's fiancée Zuri, who has hired a boat to rescue them after other search and rescue efforts were called off. Fearing her new life will be ruined, Linda leads Zuri and her boat captain to the rocky cliff where she earlier nearly fell; Zuri falls and the captain attempts to pull her up, but Linda ignores their pleas for help. She returns to camp visibly depressed and haunted, and lets Bradley go out to hunt alone, whereupon he finds Zuri's corpse washed up on the beach.

When confronted, Linda admits to Zuri's death but says it was an accident. Bradley accuses Linda of lying, distrusting her because of her story about her husband, and tries to kill her. A brutal hand-to-hand fight follows, with Linda suffering a partially gouged eye before stabbing Bradley in the side. He flees and finds a luxurious beach house on the other side of the island. Linda admits to having known about the house and reveals she murdered Zuri and her captain with a rock, and aims a shotgun at Bradley. Begging for his life, Bradley claims that he now loves Linda and wants to stay with her on the island forever, before grabbing the shotgun only to find it unloaded. Linda overpowers him and beats him to death with a golf club.

One year later, Linda has been rescued and is a wealthy celebrity after turning her survival story into a lucrative self-help career. She is interviewed at a celebrity golf tournament about the upcoming film adaptation of her best-selling memoir, in which she claims to be the only survivor of the plane crash. Linda drives away with her cockatiel Sweetie, singing along to Blondie's "One Way or Another".